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The Value Of Antihypertensive Drugs: A perspective on medical innovation

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    • Antihypertensive treatment has generated a benefit-to-cost ratio of at least 6:1 (6:1 in women and 10:1 in men).  
    • Compared to predicted levels in the absence of drug therapy, there were 9% fewer deaths from major cardiovascular disease in 2001 and 38% and 25% fewer hospital discharges for stroke…  
    • It is estimated that the number of quality-adjusted life-years achieved with each $1 million spent on antihypertensive drug therapy is between 20-50 to more than 200.  
    • A calculated approximate benefit-to-cost ratio for antihypertensive therapy is 10:1 for men and 6:1 for women.  
    • If all untreated patients with Stage I or II hypertension had been treated and achieved normal blood pressures, there would have been 420,000 fewer hospital discharges in 2002 than actually…  
    • Without antihypertensive drug therapy, there would have been about 572,000 more hospital discharges for stroke in 2002 and 261,000 more discharges for myocardial infarction.  
    • In 2001, 86,000 more premature deaths from cardiovascular disease (50,000 men and 36,000 women) would have occurred among Americans age 40 and older without antihypertensive drug therapy.  
    • From 1999-2000, average blood pressures for Americans age 40 and older would have been 10-13% higher without antihypertensive drug therapy.  
    • Cardiovascular disease mortality has declined by over 50% since 1950, contributing more than any other factor to the increase of life expectancy during the past few decades.  
    • The total economic burden of coronary heart disease is $120.6 billion; of stroke is $48.9 billion.  
    • Lifetime risk of developing hypertension is estimated at 90% for people with normal blood pressures at age 55 or 65 and who live to age 80 to 85, respectively.  
    • Treatment for hypertension using antihypertensive therapy has generated a benefit-to-cost ratio of at least 6:1.  
    • Antihypertensive therapy has had a major impact on health. Without it, 1999-2000 average blood pressures (at age 40 or over) would have been 10-13% higher, and 86,000 more premature deaths…