Silver Book reference

Identifying Potential Health Care Innovations for the Elderly of the Future: Health and costs of the future elderly

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    • Vertebral fractures are associated with a 20% reduction in QALY (Quality Adjusted Life Year) in the first 12 months, and a 15% reduction in the first 2 years.  
    • Use of existing or new drugs/compounds for Alzheimer’s prevention could result in a delay of onset of between 2 and 5 years.  
    • Widespread use of diabetes prevention drugs that enhance insulin sensitivity could result in a 50% prevention of type 2 diabetes over a 10 to 15 year period.  
    • Treating acute stroke with drugs that minimize cell death could result in a median decrease in disability of 30%. Treatment with stem cell transplants could result in a median decrease…  
    • Effectiveness of pacemaker/defibrillators to control AFib
      Widespread use of pacemaker/defibrillators to control atrial fibrillation could result in a 50% decrease in stroke.  
    • Development and widespread use of left ventricular assist devices could result in a 50% decrease in heart failure-related hospitalizations.  
    • Widespread use of telomerase inhibitors could result in a 50% cure rate and a 25% prolongation of life for 50% of eligible patients with solid tumors.  
    • Widespread use of selective estrogen receptor modulators could result in an approximately 30% decrease in breast cancer.  
    • Widespread use of cancer vaccines could result in a cure of melanoma/renal cell carcinomas and a 25% boost in survival for all other cancers.