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1 and 6-month mortality rates without treatment for sSAS

Waiting for treatment for severe symptomatic aortic stenosis (sSAS) can be deadly, with 1-month mortality at 3.7% and 6-month mortality at 11.6% (measured from the time intervention was recommended).

Malaisrie C, McDonald E, Kruse J, Li Z, et al. Mortality While Waiting for Aortic Valve Replacement. The Annals of Thoracic Surgery. 2014; 98. http://www.annalsthoracicsurgery.org/article/S0003-4975(14)01324-1/pdf

Reference

Title
Mortality While Waiting for Aortic Valve Replacement
Publication
The Annals of Thoracic Surgery
Publication Date
2014
Authors
Malaisrie C, McDonald E, Kruse J, Li Z, et al.
URL
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Categories

  • Cost of Disease
  • Human Burden

Publications

Aortic Stenosis Fact Sheet

 https://www.silverbook.org/wp-content/uploads/2017/10/AS-FS-cover.png Thumbnail

Connected Facts

Aortic Stenosis

SAS patient hospitalization costs

Symptomatic aortic stenosis (SAS) patients who do not undergo treatment cost Medicare as much as $1.3 billion each year due to rehospitalization, prolonged stays, admissions to skilled nursing facilities, and use of hospice care.

Economic Burden

Aortic Stenosis

Aortic valve disease costs

Aortic valve disease (AVD) (symptomatic and asymptomatic) costs the U.S. $10.2 billion in direct costs each year.

Economic Burden

Aortic Stenosis

Survival Rates Over 5 Years for Patients with Medically Managed Severe Aortic Stenosis

Human Burden

Aortic Stenosis

Increased hospital admissions and prolonged length of stay for patients who do not undergo treatment

Medicare severe symptomatic aortic stenosis (sSAS) patients who do not undergo treatment have an average of 1.9 hospital admissions per year and prolonged lengths of stay — 11.5 hospital days per patient-year.

Human Burden

Aortic Stenosis

All-cause mortality for aortic valve disorders

In 2014, all-cause mortality for aortic valve disorders was 34,408 in the U.S.

Human Burden

Aortic Stenosis

Lifespan of Medicare patients with sSAS who do not undergo treatment

Medicare patients with severe symptomatic aortic stenosis (sSAS) who do not undergo treatment have an average lifespan of 1.8 years.

Human Burden

Aortic Stenosis

Survival rates of sSAS patients who do not undergo valve replacement

Patients with severe symptomatic aortic stenosis (sSAS) who do not undergo valve replacement have survival rates as low as 50% at two years and 20% at 5 years after the onset of symptoms.

Human Burden

Aortic Stenosis

Prevalence of AS in Americans 75+

An estimated 12.4%, or ~2.5 million people ages 75+ in North America, have AS.

Age - A Major Risk Factor

Aortic Stenosis

Low detection rates for AS

Prevalence estimates for AS are likely low. A U.K. population screening found previously undetected HVD in 1 in 2 adults ages 65+.

Prevalence & Incidence

Aortic Stenosis

Aortic stenosis impacts majority of heart valve disease patients

Aortic stenosis (AS) is among the most common forms of heart valve disease (HVD), affecting 2% to 3% of the adult U.S. population.

Prevalence & Incidence

Related Facts

  • Moderate or severe aortic valve disease is present in 4.2% to 10.7% of the population ages 65 and older.
     
  • Five-year health care resource use in medically managed SAS patients
     
  • SAS patient hospitalization costs
    Symptomatic aortic stenosis (SAS) patients who do not undergo treatment cost Medicare as much as $1.3 billion each year due to rehospitalization, prolonged stays, admissions to skilled nursing facilities, and…  
  • Detection rate of heart murmurs
    More than 40% of heart murmurs — detected with a stethoscope and sometimes the first sign of heart valve disease (HVD) — are missed by family practitioners.  
  • Lifespan of Medicare patients with sSAS who do not undergo treatment
    Medicare patients with severe symptomatic aortic stenosis (sSAS) who do not undergo treatment have an average lifespan of 1.8 years.