Silver Book

Silver Book Fact

Use of shingles vaccines significantly reduced disease burden

Use of a live attenuated VZV (varicella-zoster vaccine) in a randomized trial reduced the burden of illness from shingles by 61.1% and the incidence of postherpetic neuralgia (PHN) by 66.5%.

Oxman, M.N., M.J. Levin, G.R. Johnson, K.E. Schmader, S.E. Straus, et al; for the Shingles Prevention Study Group. A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults. NEJM. 2005; 352(22): 2271-84. http://www.nejm.org/doi/full/10.1056/NEJMoa051016

Reference

Title
A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults
Publication
NEJM
Publication Date
2005
Authors
Oxman, M.N., M.J. Levin, G.R. Johnson, K.E. Schmader, S.E. Straus, et al; for the Shingles Prevention Study Group
Volume & Issue
Volume 352, Issue 22
Pages
2271-84
URL
Read Full Resource

Categories

  • Innovative Medical Research
  • Human Value

Related Facts

  • Measles vaccines reduced cases from 6 million to 1 million per year
    Vaccination for measles reduced the number of worldwide deaths from 6 million in 1974 to less than 1 million per year.  
  • Over 6 years, flu vaccine prevented ~13 million cases
    Over a 6-year period (2005 – 2011), the influenza vaccine prevented an estimated 13 million influenza cases–between 1.1 million and 5 million annually.  
  • Shingles vaccine could improve QALY and save money
    Vaccination of 1 million people age 60 and over with the shingles vaccine would result in 11,919 non-discounted and 8,782 discounted QALYs (quality of life years) gained and save around…  
  • Over 8 years infection control practices saved ~27,000 lives and $1.8 billion
    Infection control practices saved an estimated 27,000 lives and $1.8 billion in medical costs between 2001 and 2009.  
  • Potential value of pneumonia vaccine
    Use of PCV13 (13-valent pneumococcal conjugate vaccine) in older adults is estimated to have the potential to reduce total healthcare costs by $3.5 billion and total societal costs by $7.4…