Silver Book Fact
The annual cost of pain is greater (in 2010$) than the annual cost of heart disease ($309 billion), cancer ($243 billion), and diabetes ($188 billion)–and nearly 30% higher than the combined costs of cancer and diabetes.
Gaskin D, Richard P. The Economic Costs of Pain in the United States. J Pain. 2012; 13(8): 715-24. http://www.jpain.org/article/S1526-5900(12)00559-7/abstract