Silver Book Fact

Targeting A-type K+ channels in primary sensory neurons could provide a novel mechanism-based therapy for the treatment of bone cancer pain–one of the most severe types of chronic pain.

Duan K, Xu Q, Zhang X, et al. Targeting A-Type K+ Channels in Primary Sensory Neurons for Bone Cancer Pain in a Rat Model. Pain. 2012; 153(3): 562-74. http://www.ncbi.nlm.nih.gov/pubmed/22188869

Reference

Title
Targeting A-Type K+ Channels in Primary Sensory Neurons for Bone Cancer Pain in a Rat Model
Publication
Pain
Publication Date
2012
Authors
Duan K, Xu Q, Zhang X, et al
Volume & Issue
Volume 153, Issue 3
Pages
562-74
URL
Read Full Resource

Categories

  • Innovative Medical Research
  • Future Value

Related Facts

  • Advances in neuroimaging will continue to offer information on the brain’s functioning and how it correlates to the pain experience.  
  • Growth hormone treatment in patients with fibromyalgia is effective in reducing pain with sustained action over time.  
  • The combination of information for neuroimaging and circulatory biomarkers could improve both the sensitivity and specificity of pain diagnosis and thereby improve treatment.  
  • Acupuncture, in combination with routine care, was associated with marked clinical improvements in patients with persistent low back pain. It has also shown improvement in primary and secondary outcomes…  
  • A proteasome inhibitor was found to reduce pain and joint destruction in an animal model of osteoarthritis, suggesting that nontoxic proteasome inhibitors could offer a novel pharmacotherapy option.