Silver Book Fact
Researchers have developed several sub-types of ion channels that allow inflammation and growth factors to trigger persistent pain.
Institute of Medicine; Committee on Advancing Pain Research, Care and Education. Relieving Pain in America: A blueprint for transforming prevention, care, education, and research. Washington, DC: National Academies Press; 2011. http://www.iom.edu/Reports/2011/Relieving-Pain-in-America-A-Blueprint-for-Transforming-Prevention-Care-Education-Research.aspx