Silver Book

Silver Book Fact

Over the past 15 years, three classes of drugs have reduced mortality and improved symptoms of heart failure in patients who have decreased heart muscle function. These classes of drugs are ACE inhibitors, beta adrenergic blocking agents, and aldosterone antagonists. They each decrease mortality per year by 10-40%, and the beneficial effects of each agent have appeared in large-scale clinical trials to be additive.

Weisfeldt M, Zeiman S. Advances in the Prevention and Treatment of Cardiovascular Disease: One of the most important contributors to improved human survival is the treatment of cardiovascular disease. Health Aff. 2007; 26(1): 25-37. http://content.healthaffairs.org/cgi/content/full/26/1/25

Reference

Title
Advances in the Prevention and Treatment of Cardiovascular Disease: One of the most important contributors to improved human survival is the treatment of cardiovascular disease
Publication
Health Aff
Publication Date
2007
Authors
Weisfeldt M, Zeiman S
Volume & Issue
Volume 26, Issue 1
Pages
25-37
URL
Read Full Resource

Categories

  • Innovative Medical Research
  • Human Value

Related Facts

  • There are currently 312 medicines in development for heart disease and stroke.  
  • Every $1 spent on technological innovations in heart attack care has produced an estimated $7 gain.  
  • Pioglitazone associated with relative risk reduction in recurrent stroke
    The PROactive trial to manage glucose in diabetics with a history of cardiovascular disease, stroke, or other vascular risk factors found that treatment with pioglitazone was associated with a 47% relative…  
  • Use of antihypertensive therapies avoided an estimated $10.7 billion in 2002 direct medical costs as a result of fewer strokes. They also avoided an estimated $5.8 billion in 2002…  
  • Between 1981 and 2004, death rates for heart disease and stroke declined by about 44%.