Silver Book Fact

Opioids have been found to reduce pain intensity and improve physical functioning for patients with persistent noncancer pain. It’s important to note that a decrease in mental health functioning was also seen.

Papleontiou, Maria, Charles R Henderson, Barbara J Turner, Alison A Moore, Yelena Olkhovskaya, Leslie Amanfo, and M Carrington Reid. Outcomes Associated with Opioid Use in the Treatmetn of Chronic Noncacner Pain in Older Adults: A systematic reveiw and meta-analysis. J Am Geriatr Soc. 2010; 58(7): 1353-69. http://onlinelibrary.wiley.com/doi/10.1111/j.1532-5415.2010.02920.x/abstract

Reference

Title
Outcomes Associated with Opioid Use in the Treatmetn of Chronic Noncacner Pain in Older Adults: A systematic reveiw and meta-analysis
Publication
J Am Geriatr Soc
Publication Date
2010
Authors
Papleontiou, Maria, Charles R Henderson, Barbara J Turner, Alison A Moore, Yelena Olkhovskaya, Leslie Amanfo, and M Carrington Reid
Volume & Issue
Volume 58, Issue 7
Pages
1353-69
URL
Read Full Resource

Categories

  • Innovative Medical Research
  • Human Value

Related Facts

  • Use of stem cells to create neurons could enable the study of the response of human cells to new drugs in vitro, early in the drug development process.  
  • Statin use in mouse models show pain-alleviating effects for neuropathic pain.  
  • A meta-analysis of duloxetine, an anti-depressant, found a 50% reduction in pain at 12 weeks for diabetic peripheral neuropathy, and a 50% reduction in pain at 12 weeks for fibromyalgia.  
  • Targeting A-type K+ channels in primary sensory neurons could provide a novel mechanism-based therapy for the treatment of bone cancer pain–one of the most severe types of chronic pain.  
  • Topical NSAIDs were found in a meta-analysis to be significantly more effective than placebo in reducing persistent pain from musculoskeletal conditions.