Silver Book Fact

Opioids have been found to reduce pain intensity and improve physical functioning for patients with persistent noncancer pain. It’s important to note that a decrease in mental health functioning was also seen.

Papaleontiou M, Henderson C, Turner B, Moore A, et al. Outcomes Associated with Opioid Use in the Treatmetn of Chronic Noncacner Pain in Older Adults: A systematic reveiw and meta-analysis. J Am Geriatr Soc. 2010; 58(7): 1353-69. http://onlinelibrary.wiley.com/doi/10.1111/j.1532-5415.2010.02920.x/abstract

Reference

Title
Outcomes Associated with Opioid Use in the Treatmetn of Chronic Noncacner Pain in Older Adults: A systematic reveiw and meta-analysis
Publication
J Am Geriatr Soc
Publication Date
2010
Authors
Papaleontiou M, Henderson C, Turner B, Moore A, et al.
Volume & Issue
Volume 58, Issue 7
Pages
1353-69
URL
Read Full Resource

Categories

  • Innovative Medical Research
  • Human Value

Related Facts

  • A proteasome inhibitor was found to reduce pain and joint destruction in an animal model of osteoarthritis, suggesting that nontoxic proteasome inhibitors could offer a novel pharmacotherapy option.  
  • People with persistent pain who used complementary and alternative medicine (CAM) had lower average health care expenditures than nonusers ($3,797 versus $4,153).  
  • Nerve growth factor (NGF) has been found to be a major mediator of inflammatory and neuropathic pain and provides a new therapeutic target.  
  • A meta-analysis of pscychological interventions for chronic low back pain found small but statistically significant effects for all interventions for as long as 5 years.  
  • Targeting A-type K+ channels in primary sensory neurons could provide a novel mechanism-based therapy for the treatment of bone cancer pain–one of the most severe types of chronic pain.