Silver Book

Silver Book Fact

Fact image

In a trial with 160 participants who had type 2 diabetes, intensive intervention with multiple drug combinations and behavior modification benefited patients with respect to vascular complications and on rates of death from any cause and cardiovascular causes. One example, shown in the graph below, shows the progression of diabetic retinopathy in the two groups at 4, 8, and 13 year intervals.

Gaede P, Lund-Andersen H, Parving H, Pedersen O. Effect of a Multifactorial Intervention on Mortality in Type 2 Diabetes. NEJM. 2008; 358(6): 580-91. https://www.nejm.org/doi/full/10.1056/nejmoa0706245

Reference

Title
Effect of a Multifactorial Intervention on Mortality in Type 2 Diabetes
Publication
NEJM
Publication Date
2008
Authors
Gaede P, Lund-Andersen H, Parving H, Pedersen O
Volume & Issue
Volume 358, Issue 6
Pages
580-91
URL
Read Full Resource

Categories

  • Innovative Medical Research
  • Human Value

Related Facts

  • Intensive Glycemic Control in People with Diabetes
    Intensive glycemic control in diabetics reduced their: Adjusted mean risk of DR by 76% Risk of progression by 54% Rates of laser surgery by 56% Risk of DME by 23%    
  • To date, multiple genomewide comparisons of thousands of subjects with type 2 diabetes and controls without the disease have identified approximately twenty-five DNA variants that are significantly associated with type…  
  • Widespread use of diabetes prevention drugs that enhance insulin sensitivity could result in a 50% prevention of type 2 diabetes over a 10 to 15 year period.  
  • Improvements in key clinical measures over an average of 14.8 months in a community pharmacy health management program called the Diabetes Ten City Challenge, in which 573 patients with diabetes…  
  • Laser Treatment for DR
    Laser treatment of PDR can reduce the 5-year risk of blindness by 90%, and the risk of visual loss from DME by 50%.