Silver Book Fact

In a trial with 160 participants who had type 2 diabetes, intensive intervention with multiple drug combinations and behavior modification benefited patients with respect to vascular complications and on rates of death from any cause and cardiovascular causes. One example, shown in the graph below, shows the progression of diabetic retinopathy in the two groups at 4, 8, and 13 year intervals.
Gaede P, Lund-Andersen H, Parving H, Pedersen O. Effect of a Multifactorial Intervention on Mortality in Type 2 Diabetes. NEJM. 2008; 358(6): 580-91. https://www.nejm.org/doi/full/10.1056/nejmoa0706245