Silver Book Fact

Brain imaging is showing that pain changes the structure and function of brain regions that perceive pain, making it persistent. These brain networks and receptor targets are being identified as potential targets for future therapies.

Apkarian, Vania. The Brain in Chronic Pain: Clinical implications. Pain Manag. 2011; 1(6): 577-86. http://www.futuremedicine.com/doi/abs/10.2217/pmt.11.53

Reference

Title
The Brain in Chronic Pain: Clinical implications
Publication
Pain Manag
Publication Date
2011
Authors
Apkarian, Vania
Volume & Issue
Volume 1, Issue 6
Pages
577-86
URL
Read Full Resource

Categories

  • Innovative Medical Research
  • Future Value

Related Facts

  • Nerve growth factor (NGF) has been found to be a major mediator of inflammatory and neuropathic pain and provides a new therapeutic target.  
  • Topical NSAIDs were found in a meta-analysis to be significantly more effective than placebo in reducing persistent pain from musculoskeletal conditions.  
  • A meta-analysis of pscychological interventions for chronic low back pain found small but statistically significant effects for all interventions for as long as 5 years.  
  • People with persistent pain who used complementary and alternative medicine (CAM) had lower average health care expenditures than nonusers ($3,797 versus $4,153).  
  • Antiepileptic drugs relieve persistent neuropathic pain. One meta-analysis found gabapentin to be associated with moderate benefit (equivalent to 30% pain relief) in close to 1 in 2 patients, and…