Silver Book Fact

Brain imaging is showing that pain changes the structure and function of brain regions that perceive pain, making it persistent. These brain networks and receptor targets are being identified as potential targets for future therapies.

Apkarian V. The Brain in Chronic Pain: Clinical implications. Pain Manag. 2011; 1(6): 577-86. http://www.futuremedicine.com/doi/abs/10.2217/pmt.11.53

Reference

Title
The Brain in Chronic Pain: Clinical implications
Publication
Pain Manag
Publication Date
2011
Authors
Apkarian V
Volume & Issue
Volume 1, Issue 6
Pages
577-86
URL
Read Full Resource

Categories

  • Innovative Medical Research
  • Future Value

Related Facts

  • Researchers have developed several sub-types of ion channels that allow inflammation and growth factors to trigger persistent pain.  
  • Pregalbin, an antiepileptic drug, produced around a 32% pain reduction (a significant reduction) at week 16 versus around 20% for placebo, in patients with neuropathic pain due to spinal cord…  
  • An oral cannabinoid was found effective in relieving diabetic peripheral neuropathic pain symptoms and improving disturbed sleep, quality of life, and overall patient status.  
  • Exercise has shown to be effective in reducing persistent pain from osteoarthritis of the knee.  
  • Use of stem cells to create neurons could enable the study of the response of human cells to new drugs in vitro, early in the drug development process.