Silver Book Fact

Antiepileptic drugs relieve persistent neuropathic pain. One meta-analysis found gabapentin to be associated with moderate benefit (equivalent to 30% pain relief) in close to 1 in 2 patients, and a substantial benefit (equivalent to 50% pain relief) in close to 1 in 3 patients. Another meta-analysis found pregabalin effective in patients with postherpetic neuralgia, painful diabetic neuropathy, central neuropathic pain, and fibromyalgia.

Moore, R Andrew, Philip J Wiffen, Sheena Derry, and Henry J McQuay. Gabapentin for Chronic Neuropathic Pain and Fibromyalgia in Adults. Cochrane Database of Systematic Reviews. 2011; http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007938.pub2/abstract

Reference

Title
Gabapentin for Chronic Neuropathic Pain and Fibromyalgia in Adults
Publication
Cochrane Database of Systematic Reviews
Publication Date
2011
Authors
Moore, R Andrew, Philip J Wiffen, Sheena Derry, and Henry J McQuay
URL
Read Full Resource

Categories

  • Innovative Medical Research
  • Human Value

Related Facts

  • Opioids have been found to reduce pain intensity and improve physical functioning for patients with persistent noncancer pain. It’s important to note that a decrease in mental health functioning…  
  • An oral cannabinoid was found effective in relieving diabetic peripheral neuropathic pain symptoms and improving disturbed sleep, quality of life, and overall patient status.  
  • Advances in neuroimaging will continue to offer information on the brain’s functioning and how it correlates to the pain experience.  
  • The use of sodium oxybate (SXB) in fibromylagia patients reduced pain by 30% or more in 54-58% of patients (versus 35.2% for placebo). SXB also reduced fatigue and sleep disturbance.  
  • Topical clonidine gel significantly reduces foot pain in patients with painful diabetic neuropathy.