Silver Book Fact

Antiepileptic drugs relieve persistent neuropathic pain. One meta-analysis found gabapentin to be associated with moderate benefit (equivalent to 30% pain relief) in close to 1 in 2 patients, and a substantial benefit (equivalent to 50% pain relief) in close to 1 in 3 patients. Another meta-analysis found pregabalin effective in patients with postherpetic neuralgia, painful diabetic neuropathy, central neuropathic pain, and fibromyalgia.

Moore, R Andrew, Philip J Wiffen, Sheena Derry, and Henry J McQuay. Gabapentin for Chronic Neuropathic Pain and Fibromyalgia in Adults. Cochrane Database of Systematic Reviews. 2011; http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007938.pub2/abstract

Reference

Title
Gabapentin for Chronic Neuropathic Pain and Fibromyalgia in Adults
Publication
Cochrane Database of Systematic Reviews
Publication Date
2011
Authors
Moore, R Andrew, Philip J Wiffen, Sheena Derry, and Henry J McQuay
URL
Read Full Resource

Categories

  • Innovative Medical Research
  • Human Value

Related Facts

  • Topical clonidine gel significantly reduces foot pain in patients with painful diabetic neuropathy.  
  • Pregalbin, an antiepileptic drug, produced around a 32% pain reduction (a significant reduction) at week 16 versus around 20% for placebo, in patients with neuropathic pain due to spinal cord…  
  • In individuals with persistent low back pain, tanezumab, a humanized anti-nerve growth factor antibody, showed clinical and statistical analgesic efficacy that was superior to placebo and naproxen.  
  • The Mayo Clinic Pain Rehabilitation Center helps people with persistent pain return to an active lifestyle and has found that among patients who finish the program, nearly 84% report greater…  
  • Researchers have discovered that some types of glial cells have a major impact on persistent neuropathic pain and that targeting these cells may result in a new class of disease…