Silver Book Fact

Antiepileptic drugs relieve persistent neuropathic pain. One meta-analysis found gabapentin to be associated with moderate benefit (equivalent to 30% pain relief) in close to 1 in 2 patients, and a substantial benefit (equivalent to 50% pain relief) in close to 1 in 3 patients. Another meta-analysis found pregabalin effective in patients with postherpetic neuralgia, painful diabetic neuropathy, central neuropathic pain, and fibromyalgia.

Moore R, Wiffen P, Derry S, McQuay H. Gabapentin for Chronic Neuropathic Pain and Fibromyalgia in Adults. Cochrane Database of Systematic Reviews. 2011; http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007938.pub2/abstract

Reference

Title
Gabapentin for Chronic Neuropathic Pain and Fibromyalgia in Adults
Publication
Cochrane Database of Systematic Reviews
Publication Date
2011
Authors
Moore R, Wiffen P, Derry S, McQuay H
URL
Read Full Resource

Categories

  • Innovative Medical Research
  • Human Value

Related Facts

  • A meta-analysis of duloxetine, an anti-depressant, found a 50% reduction in pain at 12 weeks for diabetic peripheral neuropathy, and a 50% reduction in pain at 12 weeks for fibromyalgia.  
  • An opiate agonist often used for persistent pain, tramadol was found in one meta-analysis to significantly reduce neuropathic pain when compared to placebo.  
  • Researchers have developed several sub-types of ion channels that allow inflammation and growth factors to trigger persistent pain.  
  • The combination of information for neuroimaging and circulatory biomarkers could improve both the sensitivity and specificity of pain diagnosis and thereby improve treatment.  
  • An oral cannabinoid was found effective in relieving diabetic peripheral neuropathic pain symptoms and improving disturbed sleep, quality of life, and overall patient status.