Silver Book Fact

Antiepileptic drugs relieve persistent neuropathic pain. One meta-analysis found gabapentin to be associated with moderate benefit (equivalent to 30% pain relief) in close to 1 in 2 patients, and a substantial benefit (equivalent to 50% pain relief) in close to 1 in 3 patients. Another meta-analysis found pregabalin effective in patients with postherpetic neuralgia, painful diabetic neuropathy, central neuropathic pain, and fibromyalgia.

Moore, R Andrew, Philip J Wiffen, Sheena Derry, and Henry J McQuay. Gabapentin for Chronic Neuropathic Pain and Fibromyalgia in Adults. Cochrane Database of Systematic Reviews. 2011; http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007938.pub2/abstract

Reference

Title
Gabapentin for Chronic Neuropathic Pain and Fibromyalgia in Adults
Publication
Cochrane Database of Systematic Reviews
Publication Date
2011
Authors
Moore, R Andrew, Philip J Wiffen, Sheena Derry, and Henry J McQuay
URL
Read Full Resource

Categories

  • Innovative Medical Research
  • Human Value

Related Facts

  • Advances in neuroimaging will continue to offer information on the brain’s functioning and how it correlates to the pain experience.  
  • Antiepileptic drugs relieve persistent neuropathic pain. One meta-analysis found gabapentin to be associated with moderate benefit (equivalent to 30% pain relief) in close to 1 in 2 patients, and…  
  • Brain imaging is showing that pain changes the structure and function of brain regions that perceive pain, making it persistent. These brain networks and receptor targets are being identified…  
  • Topical capsaicin was found in a meta-analysis to provide a degree of pain relief to some patients with painful neuropathic conditions.  
  • Nerve growth factor (NGF) has been found to be a major mediator of inflammatory and neuropathic pain and provides a new therapeutic target.