Silver Book Fact
An opiate agonist often used for persistent pain, tramadol was found in one meta-analysis to significantly reduce neuropathic pain when compared to placebo.
Duehmke R, Derry S, Wiffen P, Bell R, et al. Tramadol for Treating Neuropathic Pain. Cochrane Database of Systematic Reviews. 2017; 6. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD003726.pub4/epdf/abstract