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All-cause mortality for aortic valve disorders

In 2014, all-cause mortality for aortic valve disorders was 34,408 in the U.S.

Benjamin E, Blaha M, Chiuve S, et al. Heart Disease and Stroke Statistics — 2017 Update: A report from the American Heart Association. Circulation. 2017; 135. http://circ.ahajournals.org/content/early/2017/01/25/CIR.0000000000000485

Reference

Title
Heart Disease and Stroke Statistics — 2017 Update: A report from the American Heart Association
Publication
Circulation
Publication Date
2017
Authors
Benjamin E, Blaha M, Chiuve S, et al
URL
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Categories

  • Cost of Disease
  • Human Burden

Publications

Aortic Stenosis Fact Sheet

 https://www.silverbook.org/wp-content/uploads/2017/10/AS-FS-cover.png Thumbnail

Connected Facts

Aortic Stenosis

2016 prevalence of aortic valve disease in America

In 2016, as many as 5.8 million U.S. adults had aortic valve disease (AVD).

Note: Alliance for Aging Research generated statistic, based on 2005 percentage prevalence
estimates by Bach et al. 2007

Prevalence & Incidence

Aortic Stenosis

Mean 5-Year Cumulative Total Medical Costs Per Medically Managed (No AVR) Severe AS Patient

Economic Burden

Aortic Stenosis

SAS patient hospitalization costs

Symptomatic aortic stenosis (SAS) patients who do not undergo treatment cost Medicare as much as $1.3 billion each year due to rehospitalization, prolonged stays, admissions to skilled nursing facilities, and use of hospice care.

Economic Burden

Aortic Stenosis

Aortic valve disease costs

Aortic valve disease (AVD) (symptomatic and asymptomatic) costs the U.S. $10.2 billion in direct costs each year.

Economic Burden

Aortic Stenosis

Survival Rates Over 5 Years for Patients with Medically Managed Severe Aortic Stenosis

Human Burden

Aortic Stenosis

Increased hospital admissions and prolonged length of stay for patients who do not undergo treatment

Medicare severe symptomatic aortic stenosis (sSAS) patients who do not undergo treatment have an average of 1.9 hospital admissions per year and prolonged lengths of stay — 11.5 hospital days per patient-year.

Human Burden

Aortic Stenosis

1 and 6-month mortality rates without treatment for sSAS

Waiting for treatment for severe symptomatic aortic stenosis (sSAS) can be deadly, with 1-month mortality at 3.7% and 6-month mortality at 11.6% (measured from the time intervention was recommended).

Human Burden

Aortic Stenosis

Lifespan of Medicare patients with sSAS who do not undergo treatment

Medicare patients with severe symptomatic aortic stenosis (sSAS) who do not undergo treatment have an average lifespan of 1.8 years.

Human Burden

Aortic Stenosis

Survival rates of sSAS patients who do not undergo valve replacement

Patients with severe symptomatic aortic stenosis (sSAS) who do not undergo valve replacement have survival rates as low as 50% at two years and 20% at 5 years after the onset of symptoms.

Human Burden

Aortic Stenosis

Prevalence of AS in Americans 75+

An estimated 12.4%, or ~2.5 million people ages 75+ in North America, have AS.

Age - A Major Risk Factor

Aortic Stenosis

Low detection rates for AS

Prevalence estimates for AS are likely low. A U.K. population screening found previously undetected HVD in 1 in 2 adults ages 65+.

Prevalence & Incidence

Related Facts

  • Undertreatment of patients with sSAS
    AS is often undertreated — one study found that 56% of severe symptomatic aortic stenosis (sSAS) patients referred to a cardiothoracic surgeon were not operated on.  
  • Increased hospital admissions and prolonged length of stay for patients who do not undergo treatment
    Medicare severe symptomatic aortic stenosis (sSAS) patients who do not undergo treatment have an average of 1.9 hospital admissions per year and prolonged lengths of stay — 11.5 hospital days…  
  • Aortic valve disease costs
    Aortic valve disease (AVD) (symptomatic and asymptomatic) costs the U.S. $10.2 billion in direct costs each year.  
  • Survival rates for SAS patients without treatment
     
  • 2016 prevalence of aortic valve disease in America
    In 2016, as many as 5.8 million U.S. adults had aortic valve disease (AVD). Note: Alliance for Aging Research generated statistic, based on 2005 percentage prevalence estimates by Bach et al. 2007