Silver Book Fact

A proteasome inhibitor was found to reduce pain and joint destruction in an animal model of osteoarthritis, suggesting that nontoxic proteasome inhibitors could offer a novel pharmacotherapy option.

Ahmed A, Li J, Erlandsson-Harris H, Stark A, et al. Suppression of Pain and Joint Destruction by Inhibition of the Proteasome System in Experimental Osteoarthritis. Pain. 2012; 153(1): 18-26. http://journals.lww.com/pain/Abstract/2012/01000/Suppression_of_pain_and_joint_destruction_by.8.aspx

Reference

Title
Suppression of Pain and Joint Destruction by Inhibition of the Proteasome System in Experimental Osteoarthritis
Publication
Pain
Publication Date
2012
Authors
Ahmed A, Li J, Erlandsson-Harris H, Stark A, et al
Volume & Issue
Volume 153, Issue 1
Pages
18-26
URL
Read Full Resource

Categories

  • Innovative Medical Research
  • Future Value

Related Facts

  • Topical NSAIDs were found in a meta-analysis to be significantly more effective than placebo in reducing persistent pain from musculoskeletal conditions.  
  • A meta-analysis of pscychological interventions for chronic low back pain found small but statistically significant effects for all interventions for as long as 5 years.  
  • Nerve growth factor (NGF) has been found to be a major mediator of inflammatory and neuropathic pain and provides a new therapeutic target.  
  • Antiepileptic drugs relieve persistent neuropathic pain. One meta-analysis found gabapentin to be associated with moderate benefit (equivalent to 30% pain relief) in close to 1 in 2 patients, and…  
  • Understanding the role of genetics in pain mechanisms is increasing and the potential now exists to conduct genome-wide screens in model organisms to look for pain-associated genes.