Silver Book Fact
A proteasome inhibitor was found to reduce pain and joint destruction in an animal model of osteoarthritis, suggesting that nontoxic proteasome inhibitors could offer a novel pharmacotherapy option.
Ahmed A, Li J, Erlandsson-Harris H, Stark A, et al. Suppression of Pain and Joint Destruction by Inhibition of the Proteasome System in Experimental Osteoarthritis. Pain. 2012; 153(1): 18-26. http://journals.lww.com/pain/Abstract/2012/01000/Suppression_of_pain_and_joint_destruction_by.8.aspx