Silver Book Fact

A proteasome inhibitor was found to reduce pain and joint destruction in an animal model of osteoarthritis, suggesting that nontoxic proteasome inhibitors could offer a novel pharmacotherapy option.

Ahmed A, Li J, Erlandsson-Harris H, Stark A, et al. Suppression of Pain and Joint Destruction by Inhibition of the Proteasome System in Experimental Osteoarthritis. Pain. 2012; 153(1): 18-26. http://journals.lww.com/pain/Abstract/2012/01000/Suppression_of_pain_and_joint_destruction_by.8.aspx

Reference

Title
Suppression of Pain and Joint Destruction by Inhibition of the Proteasome System in Experimental Osteoarthritis
Publication
Pain
Publication Date
2012
Authors
Ahmed A, Li J, Erlandsson-Harris H, Stark A, et al
Volume & Issue
Volume 153, Issue 1
Pages
18-26
URL
Read Full Resource

Categories

  • Innovative Medical Research
  • Future Value

Related Facts

  • Topical capsaicin was found in a meta-analysis to provide a degree of pain relief to some patients with painful neuropathic conditions.  
  • Acupuncture, in combination with routine care, was associated with marked clinical improvements in patients with persistent low back pain. It has also shown improvement in primary and secondary outcomes…  
  • Advances in neuroimaging will continue to offer information on the brain’s functioning and how it correlates to the pain experience.  
  • Exercise has shown to be effective in reducing persistent pain from osteoarthritis of the knee.  
  • Understanding the role of genetics in pain mechanisms is increasing and the potential now exists to conduct genome-wide screens in model organisms to look for pain-associated genes.