Silver Book

Silver Book Fact

Gene transfer process treatment for diabetic retinopathy

A gene transfer process that produces a VEGF receptor prevents retinal vascular permeability (RVP) associated with diabetes that could have value in treating diabetic retinopathy.

Ramirez, Mayda, Zhijian Wu, Bibiana Moreno-Carranza, Michael C. Jeziorski, Edith Arnold, Nundehui Diaz-Lezama, Gonzalo Martinez de la Excalera, Peter Colosi, and Carmen Clapp. Vasoinhibin Gene Transfer by Adenoassociated Virus Type 2 Products Against VEGF-and Diabetes-Induced Retinal Vasopermeability. Invest Opthalmol Vis Sci. 2011; 52(12): 8944-8950. http://www.researchgate.net/publication/51720075_Vasoinhibin_Gene_Transfer_by_Adenoassociated_Virus_Type_2_Protects_against_VEGF-_and_Diabetes-Induced_Retinal_Vasopermeability

Reference

Title
Vasoinhibin Gene Transfer by Adenoassociated Virus Type 2 Products Against VEGF-and Diabetes-Induced Retinal Vasopermeability
Publication
Invest Opthalmol Vis Sci
Publication Date
2011
Authors
Ramirez, Mayda, Zhijian Wu, Bibiana Moreno-Carranza, Michael C. Jeziorski, Edith Arnold, Nundehui Diaz-Lezama, Gonzalo Martinez de la Excalera, Peter Colosi, and Carmen Clapp
Volume & Issue
Volume 52, Issue 12
Pages
8944-8950
URL
Read Full Resource

Categories

  • Innovative Medical Research
  • Future Value

Related Facts

  • Cytokines in urine are associated with age-related macular degeneration (AMD) and could be developed as a biomarker and provide a practical tool for early detection  
  • Intensive glucose control (3 or more daily insulin injections or continuous subcutaneous insulin infusion) reduced the mean risk of retinopathy by 76% in type 1 diabetes patients who had not…  
  • A study on the impact of diet on age-related macular degeneration (AMD) found that those who took the highest amounts of carotenoids, such as lutein and zeaxanthin, had a 43%…  
  • Treatments that have been found to delay or prevent diabetic retinopathy save the U.S. $1.6 billion annually.  
  • Multifoca electroretinogram (mFERG) measures show abnormal function of the retina early in–and even prior to–diabetic retinopathy onset and could enhance monitoring of the early stages of disease progression in individuals.