Silver Book

Diabetes  /  Human Burden

Despite recent advances, diabetes continues to be a major health threat for at least 29 million Americans who have it and the 86 million Americans with prediabetes. The biggest concerns for individuals with the disease are its many complications and co-morbidities; which can cause vision loss, heart disease, stroke, and other debilitating medical conditions. With the aging of the population and the rise in risk factors like obesity, these problems are going to skyrocket, making medical innovation more critical than ever.

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    • DR Quality of Life
      A quality of life survey of legally blind DR patients found that 41% would be willing to trade their remaining years for perfect vision.  
    • Percent of Blindness in 2010 Due to DR by Region
       
    • World Blindess from DR
       
    • DR, A Leading Cause of Blindess
      DR is the one of the leading causes of blindness.  
    • People with diabetes are 60% more likely to have cataracts, than adults without the disease.  
    • People with diabetes are 40% more likely to have glaucoma, than adults without the disease.  
    • Death rates are 1.5 times higher in adults with diabetes, than in adults without the disease.  
    • Deaths from diabetes are underreported with one study finding that only 35% to 40% of people with diabetes who died had the disease listed anywhere on their death certificate.  
    • In 2010, diabetes was the 7th leading cause of death – with more than 69,000 deaths with diabetes as the underlying cause of death, and more than 234,000 with diabetes…  
    • In 2010, around 73,000 lower-limb amputations were performed in adults with diagnosed diabetes. These amputations account for around 60% of non-traumatic lower-limb amputations in people age 20 and older.  
    • In 2011, diabetes was listed as the primary cause of kidney failure in 44% of all new cases; close to 50,000 people began treatment for kidney failure due to diabetes;…  
    • 4.2 million U.S. adults age 40 and older with diabetes, had diabetic retinopathy (from 2005 – 2008).  
    • Hospitalization rates for stroke are 1.5 times higher in adults with diabetes, than in adults without the disease.  
    • Hospitalization rates for heart attack are 1.8 times higher in adults with diabetes, than in adults without the disease.  
    • Death rates from cardiovascular disease are around 1.7 times higher in adults with diabetes, than in adults without the disease.  
    • From 2009 – 2012, 65% of adults with diabetes had high LDL cholesterol or used cholesterol-lowering medications.  
    • From 2009 – 2012, 71% of adults with diabetes had high blood pressure or used medications to lower their HBP.  
    • In 2010, there were 610,000 hospital discharges among adults with diabetes.  
    • Nearly 65,700 people with diabetes had lower-limb amputations in 2006.  
    • Between 60 and 70% of people with diabetes have had mid to high levels of neuropathy.  
    • Diabetes was responsible for 44% of new cases of kidney failure in 2008.  
    • Between 2005 and 2008, 4.2 million adults age 40 and older had diabetic retinopathy.  
    • Diabetes is a leading cause of blindness for individuals ages 20 to 74.  
    • Individuals diagnosed with diabetes have a 2 to 4 times higher risk of developing heart disease, than those without the disease.  
    • In 2006, about 65,700 nontraumatic lower-limb amputations were performed in people with diabetes.  
    • More than 60% of nontraumatic lower-limb amputations occur in people with diabetes.  
    • Almost 30% of people with diabetes aged 40 years or older have impaired sensation in the feet (i.e., at least one area that lacks feeling.)  
    • About 60% to 70% of people with diabetes have mild to severe forms of nervous system damage. The results of such damage include impaired sensation or pain in the feet…  
    • In 2008, an estimated 202,290 people with end-stage kidney disease due to diabetes, were living on chronic dialysis or with a kidney transplant.  
    • In 2008, 48,374 people with diabetes began treatment for end-stage kidney disease.  
    • Diabetes is the leading cause of kidney failure, accounting for 44% of all new cases of kidney failure in 2008.  
    • Adults with diabetes have heart disease death rates about 2 to 4 times higher than adults without diabetes.  
    • Overall, the risk for death among people with diabetes is about twice that of people of similar age but without diabetes.   
    • Diabetes is the seventh leading cause of death in the United States.  
    • People with diabetes aged 60 years or older are 2–3 times more likely to report an inability to walk one-quarter of a mile, climb stairs, or do housework compared with…  
    • Diabetes is the leading cause of new cases of blindness, kidney failure, and lower-limb amputations not related to trauma.   
    • People with diabetes have a two- to fourfold increase in mortality related to heart disease and in risk for stroke, compared to people without the disease.  
    • Between 1981 and 2006, overall death rates among people over 65 dropped 21%, while the rate of deaths due to diabetes increased by 29%  
    • Diabetes was the #6 cause of death for those over 65 in 2006 with 137 per 100,000 people.  
    • In 2003-2006, 22.9% of Americans 60 years and over had diagnosed or undiagnosed diabetes.  
    • Patients with a long duration of type 2 diabetes were found to have a lower total brain volume and gray and white matter volume than those without the disease.  
    • In addition to Americans that have diabetes, an additional 30% of adults have pre-diabetes, a condition marked by elevated blood sugar that is not yet in the diabetic range.  
    • The average number of diabetes medications used per patient increased from 1.14 in 1994 to 1.63 in 2007.  
    • The estimated number of physician office visits for treated diabetes increased from 25 million in 1994 to 36 million in 2007.  
    • Adults diagnosed with diabetes have heart disease death rates about 2 to 4 times higher than those without diabetes.  
    • In 2004, stroke was noted on 16% of diabetes-related death certificates among Americans aged 65 years and older.  
    • In 2004, heart disease was noted on 68% of diabetes-related death certificates among Americans aged 65 and older.  
    • Between 1981 and 2004, age-adjusted death rates for diabetes increased by 38%.  
    • The prevalence of diabetes increased by 8.2% from 2000 to 2001. Since 1990, the prevalence of those diagnosed with diabetes increased 61%.  
    • Approximately 284,000 deaths in 2007 are attributed to diabetes.  
    • Diabetic retinopathy causes 12,000 to 24,000 new cases of blindness every year.  
    • Diabetes accounts for 45% of new cases of kidney failure in the U.S.  
    • People with diabetes are 21.8 times as likely to be admitted for skin ulcers/gangrene, 15 times as likely for peripheral vascular disease, 10 times as likely for congestive heart failure,…  
    • Due to the combined burdens and complications of diabetes, individuals at age 60 that are diagnosed with diabetes have a reduction in life expectancy and quality-of-life years of 7.3 and…  
    • Diabetes is the 6th leading cause of death, contributing to approximately 225,000 deaths per year.  
    • Diabetes is the leading cause of kidney failure, adult-onset blindness, and nontraumatic lower limb amputations.  
    • Diabetes is also a significant cause of heart disease and stroke– adults with diabetes have heart disease death rates 2 to 4 times higher and risk of stroke that is…  
    • Diabetes is the 5th deadliest disease in the United States.  
    • The risk of cardiovascular disease and stroke is 2-4 times greater in people with diabetes, compared to unaffected people.  
    • Based on preliminary data, diabetes mellitus was the sixth leading cause of death in the United States in 2004, causing 72,815 deaths.  
    • 48.5% of 64-year-olds with diabetes have 3 or more comorbidities and physical limitations–less than 10% have none.  
    • U.S. health care use attributable to diabetes by medical condition (in thousands)  
    • Health care use attributable to diabetes in the U.S., by age and type of service, 2002 (in thousands)  
    • More than 65% of Americans who have diabetes will die of some type of cardiovascular disease.  
    • Diabetes caused 176,000 cases of permanent disability in 2002.  
    • More than 60% of nontraumatic lower-limb amputations occur in diabetics.  
    • 44,400 diabetics began treatment for end-stage renal disease (ESRD) in 2002.  
    • The risk of stroke is 2 to 4 times higher in people with diabetes than in those without the disease. The risk of death from stroke is 2.8 times…  
    • In 2002, diabetes mellitus caused 54,715 deaths in people age 65 and older – ~74% of all diabetes mellitus deaths that year.  
    • In 2002, diabetes mellitus caused 73,249 deaths.  
    • Between 2002 and 2003, diabetes caused activity limitations for 41.1 of every 1,000 people between the ages of 65 and 74; for 49.4 of every 1,000 people between the ages…  
    • Approximately 60% to 70% of diabetics have mild to severe forms of nervous system damage causing impaired sensation or pain in the extremities, slowed digestion, carpal tunnel syndrome, and other…  
    • Diabetes is the leading cause of kidney failure; in 2002, it accounted for 44% of new cases.  
    • Diabetes is the leading cause of kidney disease, adult-onset blindness, and lower limb amputations. It is also a significant cause of heart disease and stroke.  
    • Diabetes was the cause of approximately 2.3 million hospital admissions, 14 million hospital days, and 70 million nursing home days in 1997.