Visual loss from subfoveal choroidal neovascularization, a characteristic of wet age-related macular degeneration (AMD), was found to have a profound impact on how patients felt about their health-related quality of life–rating it as low or lower than patients with renal failure and AIDS.
Bass, Eric B., Marta J. Marsh, Carol M. Mangione, Neil M. Bressler, Ashley L. Childs, Li Ming Dong, Barbara S. Hawkins, Harris A. Jaffee, and Paiva H. Miskala. Patients’ Perceptions of the Value of Current Vision: Assessment of preference values among patients with subfoveal choroidal neovascularization– The Submacular Surgery Trials Vision Preference Value Scale. Arch Opthalmol. 2004; 122(12): 1856-67. http://archopht.ama-assn.org/cgi/content/abstract/122/12/1856