Silver Book Fact

Statin use in mouse models show pain-alleviating effects for neuropathic pain.

Shi X, Lim T, Lee S, Zhao Y, et al. Statins Alleviate Experimental Nerve-Injury Induced Neuropathic Pain. Pain. 2011; 152(5): 1033-43. https://insights.ovid.com/pubmed?pmid=21414721

Reference

Title
Statins Alleviate Experimental Nerve-Injury Induced Neuropathic Pain
Publication
Pain
Publication Date
2011
Authors
Shi X, Lim T, Lee S, Zhao Y, et al
Volume & Issue
Volume 152, Issue 5
Pages
1033-43
URL
Read Full Resource

Categories

  • Innovative Medical Research
  • Future Value

Related Facts

  • Opioids have been found to reduce pain intensity and improve physical functioning for patients with persistent noncancer pain. It’s important to note that a decrease in mental health functioning…  
  • Targeting A-type K+ channels in primary sensory neurons could provide a novel mechanism-based therapy for the treatment of bone cancer pain–one of the most severe types of chronic pain.  
  • An opiate agonist often used for persistent pain, tramadol was found in one meta-analysis to significantly reduce neuropathic pain when compared to placebo.  
  • Brain imaging is showing that pain changes the structure and function of brain regions that perceive pain, making it persistent. These brain networks and receptor targets are being identified…  
  • A meta-analysis of pscychological interventions for chronic low back pain found small but statistically significant effects for all interventions for as long as 5 years.