Silver Book Fact

Antibiotic resistance of Klebsiella pneumoniae on the rise

Resistance of Klebsiella pneumoniae to antibiotics has dramatically increased- from 5.3% to 11.6% for third generation cephalosporins (between 1999 and 2010), and from <0.1% to 4.5% for carbapenams (between 2002 and 2010).

Braykov N, Eber M, Klein E, Morgan D, et al. Trends in Resistance to Carbapenems and Third-Generation Cephalasporins Among Clinical Isolates of Klebsiella Pneumoniae in the United States, 1999-2010. Infect Control Hosp Epidemiol. 2013; 34(3): 259-68. https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/div-classtitletrends-in-resistance-to-carbapenems-and-third-generation-cephalosporins-among-clinical-isolates-of-span-classitalicklebsiella-pneumoniaespan-in-the-united-states-19992010div/92079FCA7AE739268B12B1EA67759598

Reference

Title
Trends in Resistance to Carbapenems and Third-Generation Cephalasporins Among Clinical Isolates of Klebsiella Pneumoniae in the United States, 1999-2010
Publication
Infect Control Hosp Epidemiol
Publication Date
2013
Authors
Braykov N, Eber M, Klein E, Morgan D, et al
Volume & Issue
Volume 34, Issue 3
Pages
259-68
URL
Read Full Resource

Categories

  • Cost of Disease
  • Prevalence & Incidence

Related Facts

  • Source of 99,000 annual deaths from HAIs
    Of the 99,000 annual deaths from HAIs: 35,967 are from pneumonia 30,665 are from bloodstream infections 13,088 are from urinary tract infections 8,205 are from surgical site infections; and 11,062 are from infections at other…  
  • ~3/4 of all HAIs occur outside of ICU
    Nearly 3/4 of all hospital-acquired HAIs occur outside of the intensive care unit (ICU).  
  • Patients hospitalized for sepsis experience poor outcomes
    Compared with patients hospitalized with other diagnoses, patients hospitalized for sepsis/septicemia are: 1/2 as likely to be discharged home 2 times more likely to be discharged to other short-term care 3 times more…  
  • Risk of HAIs from hospitalization increases with age
    Hospitalized elderly patients are 2 – 5 times more likely to develop a healthcare-associated infection than younger patients.  
  • Primary sources of HAIs
    Around 2/3 of all HAIs are central-line associated bloodstream infections, catheter-associated urinary tract infections, and ventilator-associated pneumonia. Surgical site infections and Clostridium difficile (C. difficile) are also common HAIs.