Silver Book Fact

Researchers have discovered that some types of glial cells have a major impact on persistent neuropathic pain and that targeting these cells may result in a new class of disease modifying therapies.

Institute of Medicine; Committee on Advancing Pain Research, Care and Education. Relieving Pain in America: A blueprint for transforming prevention, care, education, and research. Washington, DC: National Academies Press; 2011. http://www.iom.edu/Reports/2011/Relieving-Pain-in-America-A-Blueprint-for-Transforming-Prevention-Care-Education-Research.aspx

Reference

Title
Relieving Pain in America: A blueprint for transforming prevention, care, education, and research
Publisher
National Academies Press
Publication Date
2011
Authors
Institute of Medicine; Committee on Advancing Pain Research, Care and Education
URL
Read Full Resource

Categories

  • Innovative Medical Research
  • Future Value

Related Facts

  • Use of stem cells to create neurons could enable the study of the response of human cells to new drugs in vitro, early in the drug development process.  
  • People with persistent pain who used complementary and alternative medicine (CAM) had lower average health care expenditures than nonusers ($3,797 versus $4,153).  
  • Targeting A-type K+ channels in primary sensory neurons could provide a novel mechanism-based therapy for the treatment of bone cancer pain–one of the most severe types of chronic pain.  
  • Topical NSAIDs were found in a meta-analysis to be significantly more effective than placebo in reducing persistent pain from musculoskeletal conditions.  
  • Pregalbin, an antiepileptic drug, produced around a 32% pain reduction (a significant reduction) at week 16 versus around 20% for placebo, in patients with neuropathic pain due to spinal cord…