Goel S, Bajaj N, Agaarwall B, et al. Prevalence and Outcomes of Unoperated Patients with Severe Symptomatic Mitral Regurgitation and Heart Failure. J Am Coll Cardiol. 2014; 63(2). http://www.onlinejacc.org/content/63/2/185
Pulmonary hypertension is a complication in at least 23% of patients with significant mitral regurgitation due to flail leaflet, and approximately doubles the risk of death and heart failure after diagnosis.