Silver Book Fact

Genetics can account for up to 75% of bone mineral density (BMD). Researchers have identified a gene that strongly influences peak bone mass in mice. The gene was not previously known to be involved in bone biology, and can help researchers develop drugs that could prevent or reverse the bone loss that leads to osteoporosis.

Reference

Title
NIH Fact Sheet: Osteoporosis
Authors
National Institutes of Health
URL
Read Full Resource

Categories

  • Innovative Medical Research
  • Human Value

Related Facts

  • 30 drugs are currently in development for osteoporosis.  
  • Reducing risk of fracture from 8% to 2% reduces the 5-year fracture incidence from approximately 34% to 10%.  
  • Ibandronate, a bisphosphonate, taken daily has been shown to reduce the risk of new vertebral fractures by around 62%.  
  • A systematic review of osteoporosis therapies found good evidence that many are effective in preventing fractures, but concluded that the data are insufficient to determine if any one therapy is…  
  • Treatment with zoledronic acid over a 3-year period reduced risk of vertebral fracture by around 70% and risk of hip fracture by 41%, and increased bone mineral density (BMD) by…