Silver Book Fact

Postherpetic neuralgia in shingles

Fact image

Complications, including postherpetic neuralgia (PHN) occur in ~50% of older persons with shingles.

Oxman, M.N., M.J. Levin, G.R. Johnson, K.E. Schmader, S.E. Straus, et al; for the Shingles Prevention Study Group. A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults. NEJM. 2005; 352(22): 2271-84. http://www.nejm.org/doi/full/10.1056/NEJMoa051016

Reference

Title
A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults
Publication
NEJM
Publication Date
2005
Authors
Oxman, M.N., M.J. Levin, G.R. Johnson, K.E. Schmader, S.E. Straus, et al; for the Shingles Prevention Study Group
Volume & Issue
Volume 352, Issue 22
Pages
2271-84
URL
Read Full Resource

Categories

  • Cost of Disease
  • Human Burden

Related Facts

  • Close to 1/2 of HAIs in patients 65+
    Around 45% of all hospital-acquired HAIs in 2007 were in patients age 65 and older.  
  • Majority of C. diff deaths in ages 65+
    More than 90% of deaths from C. difficile infectious occur in people ages 65 and older.  
  • Cost of pneumonia and flu more than $40 billion in 2005
    In 2005, pneumonia and influenza combined cost the U.S. $40.2 billion—$34.2 in direct costs and $6 billion in indirect mortality costs.  
  • ~1 million Americans get shingles each year
    Around 1 million Americans get herpes zoster (shingles) each year.  
  • Enormous annual direct cost of HAIs to hospitals
    The annual direct cost of healthcare-associated infections to U.S. hospitals ranges from $28.4 billion to $45 billion.