Silver Book Fact

An opiate agonist often used for persistent pain, tramadol was found in one meta-analysis to significantly reduce neuropathic pain when compared to placebo.

Duhmke R, Cornblath D, Hollingshead J. Tramadol for Neuropathic Pain. Cochrane Database of Neuropathic Pain. 2006; http://summaries.cochrane.org/CD003726/tramadol-for-neuropathic-pain

Reference

Title
Tramadol for Neuropathic Pain
Publication
Cochrane Database of Neuropathic Pain
Publication Date
2006
Authors
Duhmke R, Cornblath D, Hollingshead J
URL
Read Full Resource

Categories

  • Innovative Medical Research
  • Human Value

Related Facts

  • Targeting A-type K+ channels in primary sensory neurons could provide a novel mechanism-based therapy for the treatment of bone cancer pain–one of the most severe types of chronic pain.  
  • Brain imaging is showing that pain changes the structure and function of brain regions that perceive pain, making it persistent. These brain networks and receptor targets are being identified…  
  • The use of sodium oxybate (SXB) in fibromylagia patients reduced pain by 30% or more in 54-58% of patients (versus 35.2% for placebo). SXB also reduced fatigue and sleep disturbance.  
  • Subthalamic nuclei deep brain stimulation (STN-DBS) raises pain thresholds in Parkinson’s disease patients.  
  • A meta-analysis of antidepressants found that 1 in 3 patients with persistent neuropathic pain will get at least moderate pain relief. Another meta-analysis of duloxetine found it useful for…