Silver Book Fact

“Although high cholesterol was recognized as a key risk factor for cardiovascular disease in the 1970s, there were no good ways to reduce it. The best drug available was a grainy powder called cholestyramine. Patients mixed it with juice, but it tasted like sand–one patient said it was like drinking Miami Beach. Taking it was so unpleasant that it was prescribed for only the most severe cases.”

“Millions of people now control their cholesterol, and reduce their risk of heart disease, by swallowing a small pill just once a day. A new class of medicines, statins, was introduced in 1987 and offers a safe and effective way to lower cholesterol. One NIH official Claude Lenfant, even said that if all patients took statins according to guidelines, heart disease would no longer be the No. 1 killer.”

Categories

  • Innovative Medical Research
  • Human Value

Related Facts

  • Eliminating out-of-pocket drug costs for combination pharmacotherapy for the 423,000 Americans with drug insurance who will experience their first myocardial infarction in 2006 would save 4,736 lives, and would save…  
  • While treatment with antihypertensives has already generated a benefit-to-cost ratio of at least 6:1 (6:1 for women and 10:1 for men), more effective use of antihypertensive medication would have an…  
  • About 1/2 of the decrease in recent deaths in cardiovascular disease can be attributed to medical treatment.  
  • Survival Rates of SAS Patients with and without SAVR
    Patients with severe aortic stenosis (SAS) ages 80+ who underwent surgical aortic valve replacement (SAVR) have 1-year, 2-year, and 5-year survival rates of 87%, 78%, and 68% respectively — compared with…  
  • 277 medicines are currently in development to treat or prevent heart disease and stroke.