Silver Book Fact

A blood thinning drug was found to reduce the risk of heart attack, stroke, and cardiovascular disease by 20% in patients with acute coronary syndrome when given in addition to aspirin.

Yusuf S, Phil D, Zhao F, Mehta S, et al. Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation. N Engl J Med. 2001; 345(7): 494-502. http://content.nejm.org/cgi/content/abstract/345/7/494

Reference

Title
Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation
Publication
N Engl J Med
Publication Date
2001
Authors
Yusuf S, Phil D, Zhao F, Mehta S, et al.
Volume & Issue
Volume 345, Issue 7
Pages
494-502
URL
Read Full Resource

Categories

  • Innovative Medical Research
  • Human Value

Related Facts

  • Compared to standard coverage, 3 years of full coverage for prevention medications will reduce mortality and reinfarction rates and will save $5,974 per patient.  
  • Improvements in QoL from TAVR in SAS patients
    Symptomatic aortic stenosis (SAS) patients who underwent transcatheter aortic valve replacement (TAVR) experienced quality of life (QoL) improvements from 5.3 at baseline (10 point scale with 10=best imaginable health state)…  
  • About 2/3 of reduced mortality from cardiovascular disease is a result of medical interventions.  
  • In the 1980s, approximately 400,000 major infarctions were occurring each year in the U.S. and 40% of patients were dying within the first year. 1-year mortality is now 4-8%.  
  • Aspirin use in AFib patients
    Meta-analysis of a number of randomized controlled trials found that aspirin use in atrial fibrillation patients reduced stroke risk by an average 22%.