Valve Disease  /  Human Burden

As many as 11.6 million Americans in the U.S. have heart valve disease (HVD), and more than 1 in 10 adults ages 75 and older have HVD. Thankfully, the HVD field has experienced tremendous advances in improving survival, recovery, and quality of life for patients.

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    • Pulmonary hypertension is a complication in at least 23% of patients with significant mitral regurgitation due to flail leaflet, and approximately doubles the risk of death and heart failure after diagnosis.
       
    • Mitral regurgitation patients who did not undergo surgery saw an increased use of medical therapies from 12% to 47% over 4.5 years.
       
    • Hospital Discharges from Heart Valve Disease in 2010*
       
    • Risk of heart valve disease increases with age
      Between the ages of 18 and 44, less than 1% of the U.S. population has heart valve disease. This increases to 8.5% between ages 65 and 74, and 13.2% after…  
    • Patients with severe MR who don’t have surgery have mortality rates of 20% after 1-year and 50% after 5-years
       
    • Every year more than 25,000 Americans die of heart valve disease
       
    • Survival rates for SAS patients without treatment
       
    • Medicare patients with sSAS have an average lifespan of 1.8 years without repair or replacement
       
    • Survival rates for patients with sSAS without repair or replacement
       
    • 2016 prevalence of Americans 65+ who had AVD
      In 2016, an estimated 5.2 million U.S. adults ages 65+ had aortic valve disease (AVD).   Note: Alliance for Aging Research generated statistic, based on 2005 percentage prevalence estimates by Bach et al. 2007  
    • Detection rate of heart murmurs
      More than 40% of heart murmurs — detected with a stethoscope and sometimes the first sign of heart valve disease (HVD) — are missed by family practitioners.  
    • Survival Rates Over 5 Years for Patients with Medically Managed Severe Aortic Stenosis
       
    • Increased hospital admissions and prolonged length of stay for patients who do not undergo treatment
      Medicare severe symptomatic aortic stenosis (sSAS) patients who do not undergo treatment have an average of 1.9 hospital admissions per year and prolonged lengths of stay — 11.5 hospital days…  
    • All-cause mortality for aortic valve disorders
      In 2014, all-cause mortality for aortic valve disorders was 34,408 in the U.S.  
    • 1 and 6-month mortality rates without treatment for sSAS
      Waiting for treatment for severe symptomatic aortic stenosis (sSAS) can be deadly, with 1-month mortality at 3.7% and 6-month mortality at 11.6% (measured from the time intervention was recommended).  
    • Lifespan of Medicare patients with sSAS who do not undergo treatment
      Medicare patients with severe symptomatic aortic stenosis (sSAS) who do not undergo treatment have an average lifespan of 1.8 years.  
    • Survival rates of sSAS patients who do not undergo valve replacement
      Patients with severe symptomatic aortic stenosis (sSAS) who do not undergo valve replacement have survival rates as low as 50% at two years and 20% at 5 years after the…