Diabetes  /  Innovative Medical Research

Despite recent advances, diabetes continues to be a major health threat for at least 29 million Americans who have it and the 86 million Americans with prediabetes. The biggest concerns for individuals with the disease are its many complications and co-morbidities; which can cause vision loss, heart disease, stroke, and other debilitating medical conditions. With the aging of the population and the rise in risk factors like obesity, these problems are going to skyrocket, making medical innovation more critical than ever.

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    • DR Treatment Savings in the US
      Every year, the U.S. saves an estimated $1.6 billion by treating DR.  
    • Economics of DR Treatment
      Laser treatment plus a VEGF inhibitor achieved an incremental cost-effectiveness ratio of $12,410 per quality adjusted life year in patients with DME.  
    • Mobile Exam for DR
      Use of a mobile examination for DR screening in Finland decreased visual impairment by 86% in the covered area.  
    • Remote Interpretation of Retinal Imaging for DR
      Use of remote interpretation of retinal imaging in diabetics sent via tele-ophthalmology, improved the frequency of screening from 32% to 71% in only 12 months.  
    • Tele-ophthalmology
      Adequately trained general practitioners can screen for DR with 90% sensitivity using tele-ophthalmology.  
    • Blood Pressure Control in Patients with Diabetes
      Tight blood pressure control in type 2 diabetes patients reduced progression of DR by 34% and risk of deterioration by 47% after 9 years.  
    • Anti-VEGF Letter Improvement
      An anti-VEGF therapy for DME improved vision by more than 15 letters in approximately 36-51% of participants in a trial.  
    • Anti-VEGF Visual Improvement
      Nearly 50% of DME patients who received an anti-VEGF drug, experienced substantial visual improvement after a year of injections.  
    • Laser Treatment for DR
      Laser treatment of PDR can reduce the 5-year risk of blindness by 90%, and the risk of visual loss from DME by 50%.  
    • Intensive Glycemic Control in People with Diabetes
      Intensive glycemic control in diabetics reduced their: Adjusted mean risk of DR by 76% Risk of progression by 54% Rates of laser surgery by 56% Risk of DME by 23%    
    • DR Treatment Reduced Risk of Blindness
      Appropriate treatment can reduce the risk of blindness or moderate vision loss from DR by more than 90%.  
    • The use of insulin pumps create net cost savings, including $5886 annually per person affected and $34.9 million in increased tax revenue  
    • Detecting and treating diabetic eye disease with laser therapy can reduce the development of severe vision loss by an estimated 50% to 60%.  
    • In general, for every 10 mmHg reduction in systolic blood pressure, the risk for any complication related to diabetes is reduced by 12%.  
    • Blood pressure control reduces the risk of cardiovascular disease (heart disease or stroke) among people with diabetes by 33% to 50%, and the risk of microvascular complications (eye, kidney, and…  
    • Losing about 4 percent of your weight and keeping it off for the rest of your life could reduce your risk for a serious complication from diabetes or from dying…  
    • To date, multiple genomewide comparisons of thousands of subjects with type 2 diabetes and controls without the disease have identified approximately twenty-five DNA variants that are significantly associated with type…  
    • The Diabetes Prevention Program showed that exercise and dietary changes targeting a 7 percent weight loss in participants with prediabetes reduced type 2 development by 58 percent over three years.  
    • New and emerging technologies have made it easier for people with diabetes to manage their disease. Improved technology came in the form of a continuous glucose monitor, first approved by…  
    • The initiation of insulin therapy in the management of type 2 diabetes involves an approximate 10% increase in total health care expenditures initially, although this is offset by the consistent…  
    • In a community-based pharmaceutical care services program for 194 participants in 2001, days of sick time decreased at each interval (each year for 1-5 years) for one employer, with estimated…  
    • During the first year of a community pharmacy services program in 2003 which included 256 diabetes patients who used scheduled consultations, clinical goal setting, monitoring and collaborative drug therapy management…  
    • In a study investigating the effectiveness of diabetes management services from clinical pharmacists on patients, based on an estimated savings of $820 for each 1% decrease in A1c, the reduction…  
    • Evaluation of a Cooperative Extension Service diabetes education program showed improved nutrition knowledge, anthropometric measures and glucose control. These improvements reduced medical costs by approximately $94,010 for the 62 participants.  
    • In a community pharmacy health management program called the Diabetes Ten City Challenge, in which 573 patients with diabetes participated, the average total healthcare costs per patient per year were…  
    • An evaluation of the Diabetes Prevention Program lifestyle intervention found that providing this intervention at age 50 could prevent 37% of new cases of diabetes before age 65. If Medicare…  
    • A statin initiation intervention aimed at Medicare Part D prescription drug plan subscribers with diabetes or coronary artery disease was successful in increasing statin use among this group of members…  
    • In a community-based pharmaceutical care services program for 194 participants in 2001, mean A1c decreased at follow-ups, with more than 50% of patients demonstrating improvements at each interval (each year…  
    • For diabetes patients aged 55 and older, medical nutrition therapy was found to reduce the use of hospital services by 9.5% and physicians services by 23.5%.  
    • A diabetes self-management education program for Medicaid recipients, consisting of a 60 minute initial individual assessment of needs, followed by 12 hours of group education on nutrition and self-management, resulted…  
    • Participants in a diabetes self-management education program for Medicaid recipients, consisting of a 60 minute initial individual assessment of needs, followed by 12 hours of group education on nutrition and…  
    • During the first year of a community pharmacy services program in 2003 which included 256 diabetes patients who used scheduled consultations, clinical goal setting, monitoring, and collaborative drug therapy management…  
    • In a community pharmacy health management program called the Diabetes Ten City Challenge, in which 573 patients with diabetes participated, eye examination rates increased from 57% to 81% and foot…  
    • Projected change in 3-year diabetes-related costs and 10-year disease event rates among Medicaid recipients participating in a diabetes self-management education program consisting of a 60 minute initial individual assessment of…  
    • Average direct medical costs over time, in 2001, for 194 participants in a community-based pharmaceutical care services program for patients with diabetes.  
    • In a trial with 160 participants who had type 2 diabetes, intensive intervention with multiple drug combinations and behavior modification benefited patients with respect to vascular complications and on rates…  
    • Improvements in key clinical measures over an average of 14.8 months in a community pharmacy health management program called the Diabetes Ten City Challenge, in which 573 patients with diabetes…  
    • Due to innovation as well as other factors, the death rate in the U.S. from diabetes decreased by 3.9% in 2007 from 2006.  
    • 150 drugs are in development for diabetes. Diabetes affects 12.2 million Americans age 60 and older.  
    • LDL-C Screening: Trends, 1998-2006  
    • Blood pressure control reduces the risk of heart disease or stroke among Americans with diabetes by 33-50%.  
    • Following the current path, diabetes cases will increase by 52.9% between 2003 and 2023. If an alternative path is taken, there will be 13.3% (2.8 million) fewer diabetes cases.  
    • The risk of developing eye, kidney and nerve disease is reduced by 40% for every 1% reduction in blood glucose levels.  
    • The cost effectiveness ratio for pump therapy compared with daily insulin injections is about $18,000 per life year saved.  
    • A recent study conducted by the National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) so clearly demonstrated that lifestyle interventions reduced the risk of developing type 2 diabetes…  
    • Comprehensive foot care programs for diabetics can reduce amputation rates by as much as 45-85%.  
    • Improved control of cholesterol or blood lipids, can reduce diabetic complications by 20-50%.  
    • For every 10 mmHg reduction in systolic blood pressure, the risk of diabetic complications is reduced by 12%.  
    • Therapy that keeps blood glucose levels as close to normal as possible in type 1 diabetics, reduces damage to the kidneys by 35-56%. Experts believe that these results can be…  
    • Widespread use of diabetes prevention drugs that enhance insulin sensitivity could result in a 50% prevention of type 2 diabetes over a 10 to 15 year period.  
    • Medicines Reduce Complications of Diabetes: Diabetes patients treated with medicines are less likely to develop other health problems  
    • Disease Management Program Increases Use of Diabetes Medicines and Reduces Total Health Spending  
    • Treatment of diabetes with medication and other therapy saves $685-$950 in health care costs per patient within 1-2 years.  
    • Therapy that keeps blood glucose levels as close to normal as possible in type 1 diabetics, reduces damage to the eyes by 76%. Experts believe that these results can…  
    • One economic model predicts that if type 1 and type 2 diabetics had begun Captopril (a drug that controls blood pressure and delays the onset of kidney failure) treatment in…  
    • Every additional dollar spent on statin therapy for diabetes patients without cardiovascular disease has produced health gains valued between $7 and $31.  
    • Every additional dollar spent on screening and treating diabetic eye disease in type 2 diabetics on insulin has produced health gains valued at $36.  
    • Every additional dollar spent on intensive blood glucose control for newly diagnosed type 2 diabetic patients has produced health gains valued at $3.77.  
    • Laser treatments save up to $1.6 billion per year through prevention and treatment of blindness in diabetics.  
    • Every additional dollar spent on the overall treatment of type 2 diabetes has produced health gains valued at $1.49.  
    • Blood pressure control in diabetics reduces the risk of cardiovascular disease by 33% to 50%, and the risk of microvascular complications by approximately 33%.  
    • A study by the Diabetes Prevention Program found that the use of the drug metformin by high-risk patients reduced the risk of development of type 2 diabetes by 31%.