Cardiovascular Disease  /  Future Value

Approximately 85.6 million Americans suffer from some form of cardiovascular disease (CVD) and close to 1 in 3 deaths result from CVD. These are not only deadly but costly diseases with CVD and stroke costing around $320 billion each year.

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    • If all forms of cardiovascular disease were eliminated, life expectancy would rise by almost 7 years.  
    • Savings associated with t-PA treatment for ischemic stroke patients
      A $600 net savings is associated with each ischemic stroke patient treated with t-PA. In 2005, only 2% of all ischemic stroke patients received t-PA. If that percentage was increased…  
    • Stroke prevention through optimal anticoagulation
      If half of atrial fibrillation patients who currently receive warfarin in a routine care setting had their anti-coagulation optimized, around 9,000 strokes and more than 29,000 bleeds would be prevented.  
    • Effect of optimal anticoagulation
      If 50% of atrial fibrillation patients who currently receive warfarin in routine medical care were optimally anticoagulated, 9,852 emboli would be prevented and $1.3 billion would be saved each year.  
    • Effects of optimal anticoagulation among AFib patients
      If 50% of individuals with atrial fibrillation who do not receive prophylaxis were optimally anti-coagulated, 19,380 emboli would be prevented and $1.1 billion would be saved each year.  
    • Cost-savings associated with optimal anticoagulation in AFib patients
      If half of all atrial fibrillation patients receiving suboptimal or no anticoagulation instead received optimal anticoagulation, 28,000 strokes could be prevented each year at a savings of around $2.5 billion in direct…  
    • There are currently 312 medicines in development for heart disease and stroke.  
    • There are 23 medicines in development for stroke, the third leading cause of death after heart disease and cancer.  
    • Medicines in Development for Heart Disease and Stroke, 2008  
    • 277 medicines are currently in development to treat or prevent heart disease and stroke.  
    • According to the National Center for Health Statistics, if all major forms of cardiovascular disease were eliminated, life expectancy would rise by close to 7 years.  
    • If all forms of cardiovascular disease were eliminated, life expectancy would rise by close to 7 years.  
    • Following the current path, stroke cases will increase by 28.9% between 2003 and 2023 (estimates do not include strokes among the institutionalized population). If an alternative path is taken, there…  
    • Following the current path, heart disease cases will increase by 41.1% between 2003 and 2023. If an alternative path is taken, there will be 34.6% (9.4 million) fewer heart disease…  
    • Following the current path, pulmonary condition cases will increase by 31.3% between 2003 and 2023. If an alternative path is taken, there will be 9.1% fewer pulmonary condition cases.  
    • According to the Pharmaceutical Research and Manufacturers of America, 146 new medicines are being developed for heart disease and stroke. They include 17 for stroke, 16 for congestive heart failure,…  
    • According to the Pharmaceutical Research and Manufacturers of America, 13 medicines are currently in development for stroke.  
    • Eliminating out-of-pocket drug costs for combination pharmacotherapy for the 423,000 Americans with drug insurance who will experience their first myocardial infarction in 2006 would save 4,736 lives, and would save…  
    • The development of antioxidants that reduce oxidative damage is underway. One antioxidant that has been found, uric acid, has an even greater protective effect when combined with tPA.  
    • While treatment with antihypertensives has already generated a benefit-to-cost ratio of at least 6:1 (6:1 for women and 10:1 for men), more effective use of antihypertensive medication would have an…  
    • New approaches are under development to reduce ischemic stroke damage and other damage occuring because of stroke.  
    • A major objective is to control blood pressure and preempt primary and secondary stroke. Assessing specific antihypertensive therapies will identify specific treatments that will lower blood pressure.  
    • If antihypertensive medication were widely used, it would result in an estimated increase in life expectancy (averaged over the entire population) of 0.5 years in men and 0.4 years in…  
    • The projected economic value of eliminating deaths from stroke is $7.6 trillion.  
    • Greater use of clot-busting drug t-PA in ischemic stroke patients could save the health care system over $100 million a year.  
    • Treating acute stroke with drugs that minimize cell death could result in a median decrease in disability of 30%. Treatment with stem cell transplants could result in a median decrease…  
    • Development of a neuroprotective drug could potentially reduce disability from stroke by 50%.  
    • Effectiveness of pacemaker/defibrillators to control AFib
      Widespread use of pacemaker/defibrillators to control atrial fibrillation could result in a 50% decrease in stroke.  
    • The projected economic value of eliminating deaths from heart disease is approximately $48 trillion.  
    • Initiating and continuing beta-blocker use in most first-time heart attack survivors for 20 years would result in 72,000 fewer coronary heart disease deaths, 62,000 fewer heart attacks, and 447,000 gained…  
    • Development and widespread use of left ventricular assist devices could result in a 50% decrease in heart failure-related hospitalizations.